EDCs, Synthetic Hormones

中间性 - 中间性性象谱

中间性的原因 - 环境因素

内分泌干扰化学物/合成激素(EDCs, Synthetic Hormones)

近年来,很明确,环境污染已经导致了许多野生雄性动物的雌性化。例如:某些生活在工业化学物污染的湖泊和河流里的鱼和青蛙已经出现雌雄双性的症状,并由此而不能繁殖。这一后果会继而显著地影响到它们的种群数量。在此所提及的化学物称为内分泌干扰化学物(endocrine disrupting chemicalsEDCs)正如其名称所指明的那样,它们干扰诸如卵巢和睾丸这样的内分泌腺的生理功能,也就是说它们在生物体内妨碍激素的固有的生理作用。所以,它们能够导致包括性器官异常发育在内的各种各样的体格问题。欲描述全部的这些化学物则超出了本教程的范围,在此也不可能列举它们的多种效应。不管怎样,这些化学物对人的中间性的实际而潜在的作用仍然不明,并且一直受到人们的观测和探讨。不过,在孕妇的有关内容中曾经描述过的特定的激素类药物孕酮(Progestin,也称为黄体酮——译者注)干扰内分泌功能的作用则是毋容置疑的。这种用于避孕的药物,在(上个世纪)5060年代,曾用来防止流产。然而,它没有预期目的的那种效应,却对女胎有着男性化发育的作用。当出生时,她们的性器官在相当大的程度上像男性的性器官。二乙基-已烯雌酚 (diethylstilbestrolDES) 是一种人工合成的雌激素,从1940年代到1970年代早期,曾一度被人确信是防止流产的药物。也是这样,它并不像预期的那样有防止流产的作用,而是有非常严重的无法预料的副作用。其中的副作用是引起新生儿的中间性的病症并增加用药的女孩和孕妇的健康风险。
所有这些观察资料再一次阐明,中间性确确实实是一个伴随着各种各样病因的发病程度不同的问题。所以,既然每一个病例是有差别的,那么所有的中间性作为个体必须和值得区别看待和分别治疗。他们在各个方面是有着自己权益的完整的人。虽然他们在统计学上是少数,他们有权得到大多数人认可的优先照应的权益。

 ()用于欧共体的标志:对环境危险 
这封画了一颗枯死的大树和一条死鱼的标志必须被张贴在那些可能危害自然环境的化学物的包装上。

 ()美国食品药物管理局的标贴 
在美国,食品药物管理局(FDA)通过确保药品、生物制品、医疗仪器、食物、化妆品和放射线产品的安全来保护公众健康。

Intersexuality - The Intersexual Spectrum

Causes of Intersexuality - Environment

EDCs, Synthetic Hormones

In recent years, it has become clear that environmental pollution has caused the feminization of many male animals in the wild. For example: Certain fish and frogs that were exposed to industrial chemicals in lakes and rivers have developed intersexual conditions and thus an inability to reproduce. The result is a continuing dramatic decline in their populations. The chemicals involved here are known as endocrine disrupting chemicals (EDCs). As the name indicates, they disrupt the workings of endocrine glands like ovaries and testicles, i.e. they interfere with essential hormonal processes inside the body. Thus, they can lead to various physical problems, including the atypical development of sex organs. Describing all of these chemicals lies outside the scope of this course. Neither is it possible here to list their many effects. At any rate, their actual and potential role in human intersexuality is still unclear and continues to be investigated. However, there is no doubt about certain hormonal medications that were once prescribed for pregnant women: Progestin, widely used in contraception, was, in the 50’s and 60’s, administered to prevent miscarriages. While it was not effective for that purpose, it had a virilizing effect on female fetuses. At birth, their sex organs resembled, in various degrees, those of males. DES (diethylstilbestrol) a synthetic form of estrogen, was, from the 1940s to the early 1970s, also given in the belief that it would prevent miscarriages. Again, it did not work as intended but had very severe unforeseen effects. Among these were intersexual conditions in newborn boys and increased health risks for girls and for the mothers who took the drug.
All of these observations once more illustrate that intersexuality is indeed a matter of degree with a great variety of causes. Therefore, since each case is different, all intersexes must be - and deserve to be - seen and treated as individuals. They are persons in their own right and fully human in every respect. While they are in a statistical minority, they are entitled to all privileges that the majority takes for granted.

 (Left) Symbol used by the European Union: Dangerous for the Environment
The symbol, which shows a dead tree and a dead fish, must be displayed on the packages of all chemicals that could harm the natural environment.

(Right) Logo of the US Food and Drug Administration
In the USA, the FDA is responsible for protecting the public health by assuring the safety, efficacy, and security of drugs, biological products, medical devices, foods, cosmetics, and products that emit radiation.
 

[Course 3] [Description] [How to use it] [Introduction] [Problems in Females] [Problems in Males] [Intersexuality] [Introduction] [Intersexual Spectrum] [Dealing w. Intersex.] [Additional Reading] [Examination]